Puppies can typically go outside for short periods of time once they have received their necessary vaccinations and are at least 16 weeks old. Until then, it is recommended to keep puppies indoors or in a safe, enclosed area to prevent exposure to potentially harmful viruses and diseases.

However, it's important to note that the exact timing may vary based on several factors, including the breed, size, and health of the puppy, as well as the prevalence of certain diseases in the area. It's always best to consult with a veterinarian for specific guidance on when it's safe to take your puppy outside.